|
|
|
Home -> Shop By Store -> Glutamine
Glutamine
What is Glutamin ?
Glutamine is the most abundant amino acid in the body. A decrease of plasma glutamine concentrations is found in catabolic stress and is related to susceptibility to infections. Glutamine is known to modulate lymphocyte activation; however, little is known about glutamine modulation of cell death of activated human T cells.
Using Jurkat T cells, we investigated glutamine modulation of T-cell apoptosis activated by PMA plus ionomycin. We found that glutamine at various concentrations significantly enhanced IL-2 production, cell proliferation, and cell viability of Jurkat T cells. Glutamine also decreased the number of apoptotic cells stimulated with PMA plus ionomycin as demonstrated by flow cytometry. Meanwhile, glutamine down-regulated CD95 and CD95L expression, but up-regulated CD45RO and Bcl-2 expression in activated T cells. Further investigation of CD95-mediated caspase activities revealed that supplementation of glutamine significantly decreased caspase-3 and caspase-8 activities in activated T cells. Since oxidative stress is closely associated with induction of lymphocyte apoptosis, we found that glutamine significantly increased glutathione (GSH), but decreased reactive oxygen species levels in activated T cells.
|
| |
|
|
|
© Copyright 2005 - 2012 PillPod.com
Statements
made, or products sold through this web site, have not been evaluated by
the Food and Drug Administration. They are not intended to diagnose, treat,
cure, or prevent any disease. You should carefully read all product packaging
and labels. If you have or suspect that you have a medical problem, promptly
contact your medical professional. We are not responsible for incorrect
or outdated product descriptions and/or images.
|
