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Home -> Shop By Store -> Fish OilFish OilAbout Fish OilWith the focus on concepts such as the glycemic index, macronutrient ratios, and food groups, essential fatty acids (EFAs) are one of the most neglected aspects of nutrition in modern society. One can have a diet that is nutritious by most standards and still underconsume EFAs. Omega-3s are of particular importance in today's world. A deficiency of omega-3 EFAs in the diet, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), may play a strong role in many of the widespread and interrelated conditions of today, such as cardiovascular disease, inflammatory conditions, and obesity. Fish oil supplements are also a more convenient and less expensive source of EFAs. What does Fish Oil do? One of the primary benefits of fish oil supplementation is improvement in body composition, as dietary fatty acid composition plays an important role in the accumulation of excessive body fat. A reduction in fat mass is to be expected, as well as fat being less likely to be distributed in the abdominal area. There are quite a few mechanisms of action, one of the most important being activation of peroxisome proliferator-activated receptor alpha (PPARalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma), which in turn increases the production of various enzymes that break down fat Fish oil also deactivates a number of lipogenic (fat forming) enzymes . Many studies in rats have found a diet high in fish oil to significantly reduce fat accumulation .This reduction is dose-dependant.Also, fish oil causes less relative distribution of fat in the abominal area in rats gaining weight compared to saturated fat and increases lipid mobilization in visceral adipose tissue .Fish oil has definite potential in the treatment of obesity Fish oil may be especially useful during a period of weight gain due to the fat redistribution. Fish oil plays a very important role in brain development and the maintenance of normal brain function in adults. The impact during development is significant enough that maternal supplementation with fish oil has been shown to increase the IQ of children at age four by an average. Fish oil also fights stress and depression. Multiple studies have found a direct association between depression and omega-3 content in various tissues of the body, including the content in adipose tissue, which is a marker of long-term dietary fat intake . Supplementation with DHA increases levels of both serotonin and dopamine in rats without affecting norepinephrine . Fish oil has many anti-inflammatory properties and for this reason has been explored in a number of inflammatory and autoimmune conditions. These include rheumatoid arthritis, Crohn's disease, ulcerative colitis, psoriasis, lupus erythematosus, multiple sclerosis, migraine headaches, asthma, and cystic fibroris, and it usually has a significant beneficial effect.Mechanisms of action include displacement of arachidonic acid (which is pro-inflammatory), suppression of proinflammatory cytokines, and changes in adhesion molecule expression . Fish Oil is safe. Fish oil consumption is generally safe and well tolerated, with less adverse effects than other dietary oils. |
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